5-Amino-1MQ

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a permeable, small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Unlike the previous peptides, 5-Amino-1MQ is a synthetic quinoline derivative that targets metabolic processes at a cellular level by preventing the degradation of NAD+ precursors.

Research Applications

5-Amino-1MQ is studied for its ability to reverse obesity from high-fat diets and enhance muscle function by inhibiting NNMT, increasing NAD+, and activating the SIRT1 gene. It improves muscle stem cell proliferation and myofiber size in preclinical models, indicating potential uses for sarcopenia and age-related muscle loss. The compound is also researched for improving body composition by reducing fat storage without impacting overall food intake.

Product Specifications

• Molecular Formula: C10 H11 N+2 (Cation) or C10 H11 IN2 (Iodide salt)

• Purity: ≥99% (HPLC verified)

• Format: Lyophilised powder

Storage & Stability Protocols

• Lyophilised Powder: Stable at room temperature for 3 weeks; store at -20°C for up to 48 months.

• Reconstituted Solution: Store at 2–8°C, stable for 21–30 days.

• Protection: Keep vials away from light, heat and moisture. 

COA available on request

Note: This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human or animal consumption or medical use.